Nitrous Oxide, or laughing gas, is commonly used by dentists and surgeons as a sedative (or anaesthetic) that’s inhaled through a small mask.
People with low levels of vitamin B12 or a MTR (B12) enzyme which isn’t fully functional are “absolutely contraindicated” for Nitrous Oxide use. This is because it can cause neurological damage such as memory loss and problems with walking following use.
Try to avoid giving it to your children if possible. Ask your Dr if there is something else they can use. If you definately must use it, check your child’s B12 levels prior to surgery and give them a B12 supplement.
http://anesthesiology.pubs.asahq.org/article.aspx…
http://anesthesiology.pubs.asahq.org/…/JASA/931047/20TT4.png
Drugs to Avoid with MTHFR (you already know to avoid Folic Acid)
• Antacids (deplete B12)
• Cholestyramine (deplete cobalamin and folate absorption) – common in gallbladder issues during pregnancy!
• Colestipol (decrease cobalamin and folate absorption)
• Methotrexate (inhibits DHFR)
• Nitrous Oxide (inactivates MS)
• High Dose Niacin (depletes SAMe and limits pyridoxal kinase = active B6)
• Theophylline (limits pyridoxal kinase = active B6)
• Cyclosporin A (decreases renal function and increases Hcy)
• Metformin (decreases cobalamin absorption)
• Phenytoin (folate antagonist)
• Carbamazepine (folate antagonist)
• Oral Contraceptives (deplete folate)
• Antimalarials JPC-2056, Pyrimethamine, Proguanil (inhibits DHFR)
• Antibiotic Trimethoprim (inhibits DHFR)
• Ethanol
• Bactrim (inhibits DHFR)
• Sulfasalazine (inhibits DHFR)
• Triamterene (inhibits DHFR)
(c) 2013: Benjamin Lynch, ND
Development of an Anesthetic Protocol for Patients with Known or Suspected Mitochondrial Disorders- A Quality Improvement Initiative
anesthesia_considerations_in_children_with_down_syndrome
Anesthetic_consideration_in_downs_syndrome–a_revi
