‘You cannot use just anything in nature because many natural products do the opposite to neuro biochemistry in DS than it would in a typical brain. For instance, many products on the market are known antioxidants. It’s a fact that people with DS suffer from oxidative stress. So why not just grab every single natural antioxidant and give it to them? Big mistake. In every cell there is an antioxidant triad of enzymes that function together to change hydrogen peroxide into water and oxygen for the cells usage. But, many of these products, or combination products, work by upregulating the genes in this triad. They have no true antioxidant properties of their own. In DS, the gene for one part of this enzyme triad, Superoxide Dismutase 1 (SOD1) is over expressed. The balance is so disrupted that it simply doesn’t function. Without this enzyme triad functioning your child’s cells have a very short life. This leads to cognitive decline and paves the way for Alzheimer’s disease and premature death. So you must be extremely careful what you give your child because what is beneficial for typical people can be dangerous for people with Down syndrome.
While it is not possible to down regulate SOD1 selenium something unique, it upregulates the other two triad enzymes to restore the balance of the antioxidant enzyme system. This was proven in the Miguid study on Nutrigenetic Intervention published in 2001. In that study, SOD1 was NOT effected by the protocol but Catalase and Glutathione Peroxidase were significantly elevated.
In this case we utilized nutrients to directly target Catalase and Glutathione Peroxidase to instruct the genes to create more of those enzymes. While, at the same time, we deliberately avoided anything that would effect SOD1. The result was a minor miracle, the partial restoration of the antioxidant triad in DS. (See Miguid Study http://trisomy21research.org/2017/09/19/the-miguid-study-on-nutrivene/). This had never been done before and only Nutrigenetic Intervention can and does do this today.
Since the Miguid Study, scientists have gone after numerous other over expressed genes, disrupted neurotransmitters and disfunctioning biochemical pathways. The results, thus far, have been astonishing. In the future we will continue to manipulate the Down syndrome genome safely and effectively utilizing those things provided, with our gratitude, by our Creator.’
Dixie Lawrence, Biochemist, T21 Specialist
